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Welcome to OncoNotes, a bimonthly e-newsletter from Memorial Sloan-Kettering Cancer Center that provides physicians with news and information about advances in cancer prevention, treatment and research, clinical trials, and upcoming CME programs.

For additional information about Memorial Sloan-Kettering Cancer Center, please visit our Web site at http://www.mskcc.org. We welcome your comments and questions about OncoNotes. Please e-mail us at OncoNotes@mskcc.org.

Monoclonal Antibody Drugs for Cancer Treatment
The strategy of using monoclonal antibodies was first described in the late 1970s with the promise that they could be developed to kill cancer cells with few or no side effects. For the treatment of several types of cancer, including certain lymphomas, leukemias, neuroblastoma, and HER2-positive breast cancer, monoclonal antibodies are already offering this advantage. While their use has yet to be fully optimized, they still clearly benefit many patients.

New Outpatient Clinic Enhances Adult Bone Marrow Transplant Service
MSKCC recently established a dedicated outpatient clinic for adult allogeneic bone marrow transplant patients. This new clinic allows us to provide our rapidly growing population of transplant patients with the follow-up treatments they need, including blood transfusions, intravenous drugs, and respiratory treatments efficiently, comfortably, and safely.

Research Provides Information About How Cancer Metastasis Occurs
Investigators at MSKCC have found new clues about how metastatic cancer can form long after a primary tumor has been removed. The study, published in Science in September, used mouse models to mimic the spread of breast cancer to the lungs.

MSKCC Investigators Discover Technique to Restore and Enhance Intestinal Immune Defense
Infection by antibiotic-resistant bacteria is a dangerous complication of broad-spectrum antibiotic therapy. Treatment with antibiotics impairs natural immune defenses in the intestines, allowing antibiotic-resistant microbes to flourish. Now MSKCC researchers have found a way to restore innate immune defense in the intestines and enhance resistance to vancomycin-resistant Enterococcus (VRE), a potentially harmful antibiotic-resistant bacterium.

CLINICAL TRIAL: Survey and Blood Sample Collection for “Never Smokers” with Lung Cancer
Researchers at Memorial Sloan-Kettering have initiated a clinical study that will survey and collect blood samples from patients with lung cancer who have never smoked. Blood samples will be used for so-called "whole genome association studies" to look for differences between the genomes of never smokers with and without lung cancer. This may help to identify new genes, which may explain and predict why certain patients develop lung cancer without having smoked tobacco.

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